![]() Millions of people have received the vaccine with few side effects. The EMA is an agency of the European Union (EU. YOU SAID: the good of the many outweigh the good of the few. Despite the possible side effects of the mRNA vaccines, the EMA stressed that they believe the benefits of the vaccines far outweigh the risks. I’m sad that you don’t see the sacrifice we are all making as very small when weighed against a preventable loss of life. The good of the many outweigh the good of the few. I’m sad that you see a “stay at home” plan as a loss of your rights. That the good of the many outweighs the good of the few is gospel truth for a wide swath of the population, including many philosophers, economists, and politicians. ![]() ![]() And if the ICU beds are all full of people with COVID-19, then people who are injured in car accidents, firefighters with smoke inhalation, police officers shot by bad guys, and and anyone else who might need an ICU won’t get a bed. In the film, Spock brings the meaning of these words to a poignant reality by sacrificing his life to save the life of the. Of course, Spock himself violates this edict in some circumstances. The words of Leonard Nimoy as the character Captain Spock in the film, Star Trek II: The Wrath of Khan. 0.15 In The Wrath of Khan (1982), Spock says, Logic clearly dictates that the needs of the many outweigh the needs of the few. If all the ICU beds are full of people getting their short-term care, then more people who need that short-term care won’t get it, and they will die. The needs of the many outweigh the needs of the few or the one. ![]() Most people with COVID-19 will recover on their own, a small number will need a brief time in the ICU, and an even smaller number will die no matter what. Most of us will probably still get the virus, but the point of staying home is to slow down the spread, so that hospitals aren’t overwhelmed by a huge rush of sick people. Yes, the point of the many staying at home is indeed to reduce the spread of the virus so that our most vulnerable members of the population will be less likely to die. ![]()
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![]() If you use a feature that's not covered by the free version (you're told which ones aren't free when you use them), the saved PDF file will have a watermark attached to the corner of every page. Many of the features are free (like editing the text), but some are not. ![]() This is really helpful if you're editing a PDF with lots of forms, such as an application. One nice feature is the ability to highlight all the form fields so that you can easily spot where you need to fill in. All the options and tools are simple to understand, however, and they're categorized into their own sections for easier management. ![]() There are lots of features, so it might seem overwhelming at first. You can save the edited PDF back to your computer or to any of those cloud storage services. You can load PDFs from your computer, a URL, SharePoint, Google Drive, and Dropbox. If you stick to just the free features, however, you can still do some editing to the file and save it back to your computer. If you use a non-free feature, the PDF will save with a watermark on every page. PDF-XChange Editor offers some great tools, but not all of them are free to use. Sejda PDF Desktop runs on Windows, macOS, and Linux. This tool works no matter which operating system you use. For example, the desktop edition supports more font types and doesn't let you add PDFs by URL or from online storage services as the online editor does (which supports Dropbox, OneDrive, and Google Drive).Īnother neat feature is the web integration tool that lets PDF publishers provide a link for their users that they can simply click to automatically open the file in this editor.Īll uploaded files are automatically deleted from Sejda after two hours. There are some differences between the online and desktop versions that you should know about. You can get the desktop version if you'd rather use it that way. Plus, this tool can run entirely in your web browser, so it's easy to get going without having to download any programs. Most editors only let you edit the text you add yourself, or they support text editing but then throw watermarks all over the place. ![]() Sejda PDF Editor is one of the very few PDF editors that actually lets you edit pre-existing text in the PDF without adding a watermark. ![]() Limited to docs with fewer than 200 pages. For example, use one to edit the PDF text (if that's supported), and then put the same PDF through a different editor to do something supported in that program (for example, to edit a form, update an image, or remove a page). That's the quick way-but do bear in mind that, typically, a web-based editor isn't as fully featured as its desktop counterpart, plus the file is exposed to the internet (which might be of concern if it contains sensitive content).īecause not all of these editors support the same features, and some are restricted in what you can do, remember that you can process the same PDF in more than one tool. Some of these are online editors that work right in your web browser, so all you have to do is upload your PDF file to the website, make the changes you want, and then save it back to your computer. Looking for a truly free PDF editor that lets you not only edit and add text but also change images, add your own graphics, sign your name, fill out forms, and more? You came to the right place: We've researched these types of apps to come up with a list of exactly what you're looking for. ![]() ![]() Applications can be moved from one display to another, or can be on more than one display simultaneously.The Display applet, in Control Panel or the Devices tab of the Intel® Graphics Control Panel window, can be used to configure the size and position of each display (Figure 2).Multidisplay allows for a large Windows* desktop that spans multiple displays, creating more screen viewing area than one display.Extended Desktop is the ability of one adapter with at least two display pipes to support multiple display configurations.Noteįollow these instructions if you do not know how to open the Intel® Graphics Control Panel.įigure 1: Intel® Dual Display Clone as seen in Windows XP Advanced Display Properties Intel Graphics Devices tab. Select the Primary Device and the Secondary Device and click Apply. To activate Intel Dual Display Clone, click the Intel® Dual Display Clone icon on the Devices tab of the Intel® Graphics Control Panel window.For example, one pipe driving a standard monitor plugged into the VGA port while the other pipe drives an overhead projector supporting specific resolutions and refresh rates. Intel Dual Display Clone is beneficial when using displays of various types and sizes.Each can have a different refresh rate, color depth, and resolution for optimum display on each device. Each display device can be configured independently. Intel Dual Display Clone is used to drive multiple displays with the same content. Multidisplay option: Intel® Dual Display Clone Intel Dual Display Twin utilizes one of the display pipes to drive the same content at the same resolution, color depth, and refresh rates on each display. Multidisplay option: Intel® Dual Display Twin But, the GMCH graphics engine can work in conjunction with a PCI graphics adapter. ![]() The GMCH graphics engine is incapable of running in parallel with an external PCI Express* graphics device. NoteĪn Advanced Digital Display 2 (ADD2) card must be installed as an added display adapter for dual display capabilities. These Intel graphics products support Dual Display Clone, Dual Display Twin, and Extended Desktop. Timings and resolutions for these two images can be different. These products have several ports for its two pipes and supports up to two images on different displays. ![]() Microsoft Windows 2000*, Windows XP* and newer operating systems have enabled support for multidisplay. Support for multidisplay on older Intel® graphics products Another possible configuration sends the same content to different displays to give a presentation to a large audience. For example, two devices can be driven independently with different content, resolutions, and color depth to increase desktop space. Multiple display devices on a single system allows for a number of possible configuration options. For the Multiple Display FAQ for newer Intel® graphics products, see Multiple Display FAQ.Ĭlick or the topic for details: What is multidisplay? ![]() ![]() ![]() The researcher obtained total cure in 33% of patients using radical mastectomy and en bloc resection of breast tissue and axillary lymph nodes. Halsted highlighted the importance of the lymphatic system in the management of breast cancer. ![]() The route of lymphatic dissemination was initially demonstrated in animal models using a variety of injected tracers. The first studies on the role of the lymphatic system in the spread of cancer cells and metastasis were performed in the 1950s. Virchow postulated that lymph nodes function as filters. The functions and diseases associated with the lymphatic system have been extensively studied since the seventeenth century. Most cancers in humans are epithelial in nature and such neoplasms metastasize via lymphatics therefore, the lymphatic system plays a pivotal role in a significant number of malignancies. Since then, the procedure has been used for other malignancies, including breast, vulvar, and cervical cancer. In 1992, Morton was the first to identify the presence of regional lymph nodes and to map SLNs using isosulfan blue in patients with melanoma. Identification and biopsy of the SLN can correctly indicate the status of the draining lymph node basin. Labeled lymph nodes are surgically excised and histologically examined for the presence of disease. Clinical identification of these nodes is performed via injection of numerous types of tracers, dyes, and radioisotopes into the peritumoral site depending on the type and location of the tumor. SLN biopsy is based on an ordered dissemination of tumor cells from peritumoral lymphatics to the SLN, and then to more distant lymph nodes. Currently, SLN biopsy is a routine procedure for these pathologies plus cervical and vulvar cancer as well. The first SLN studies included melanoma and breast cancer patients. SLN is the first lymph node to which a tumor initially drains. The present literature review aimed to provide an overview of the basic concepts and clinical aspects of SLN biopsy, including the brief history and relevant anatomical, pathophysiological, and clinical aspects in the light of the most current scientific data. In some instances, even in pediatric patients, SLN biopsy can be a useful tool for minimizing the risks and morbidity associated with surgery. After many years of research on various types of malignancies SLN biopsy has become the standard of care in the treatment of melanoma, breast, vulvar, and cervical cancer, sparing many patients from the morbidity associated with ultraradical surgery. The SLN concept was initially proposed in 1960 and is currently considered among the most important advances in cancer therapy. When SLN is tumor-free, systematic retroperitoneal lymphadenectomy (LND) can be omitted leading to a significant reduction in surgery-related morbidity. In other words, SLN biopsy could be considered a triage procedure. Detection and pathologic examination of the SLN can potentially alter the extent and radicality of oncologic surgery. Sentinel lymph node (SLN) is the first lymph node to receive drainage directly from a tumor. This literature review aimed to present an overview of the basic concepts and clinical aspects of SLN biopsy in the light of the current research. Along with the introduction of new technologies, such as the fluorescent dyes indocyanine green (ICG) and near-infrared fluorescence (NIR), and pathologic ultrastaging, SLN detection rate has increased and false-negative rate has decreased. After many years of observation and research on its use in various malignancies SLN biopsy has become the standard surgical treatment in patients with malignant melanoma, breast, vulvar, and cervical cancers. SLN biopsy was first reported in 1960 but took approximately 40 years to come into general practice following reports of good outcomes in patients with melanoma. Detection and pathological examination of the SLN is an important oncological procedure that minimizes morbidity related to extensive nodal dissection. Sentinel lymph node (SLN) is the first node to receive the drainage directly from a tumor. ![]() ![]() If you are taking TRIBENZOR do not drink alcohol. Cyclosporine or tacrolimus (medicines used to alter the way your immune system works)Ībout alcohol and other drug interactions.Cholesterol-lowering medicines (including simvastatin).Sleeping pills and antiseizure medicines called barbiturates. ![]() Cholesterol-lowering medicines (e.g., cholestyramine, colestipol).If you take TRIBENZOR, tell your doctor if you also take: If you take BENICAR HCT, tell your doctor if you also take: CYP3A inhibitors and CYP3A inducers (medicines that affect the liver).Simvastatin, a cholesterol-lowering drug.Lithium for certain types of depression.Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).Potassium supplements or a salt substitute that contains potassium.Other medicines for high blood pressure or a heart problem.If you take AZOR, tell your doctor if you also take: If you take BENICAR, tell your doctor if you also take: These medicines may include prescription and nonprescription medicines, vitamins, and herbal supplements: Some of your other medicines and BENICAR, BENICAR HCT, AZOR, or TRIBENZOR could affect each other. Tell your doctor about all the medicines you take Heart problems (including coronary heart disease and narrowing of the aortic valve).Let your doctor know if you have these, or any other, medical conditions: Also let your doctor know if you have any of the health conditions listed below: Tell your doctor if you are allergic to any of the ingredients in BENICAR, BENICAR HCT, AZOR, or TRIBENZOR (see Full Product Information for a list of the ingredients in BENICAR, BENICAR HCT, AZOR, or TRIBENZOR, as applicable). Let your doctor know about any health conditions you may have (Please see Boxed WARNING regarding Fetal Toxicity). ![]() You and your doctor should decide if you will take BENICAR, BENICAR HCT, AZOR, or TRIBENZOR or breast-feed. A medicine in BENICAR HCT and TRIBENZOR can pass into your breast milk. Also tell your doctor if you are breast-feeding or plan to breast-feed. Children of any age should not receive AZOR, BENICAR HCT, or TRIBENZOR.īefore taking BENICAR, BENICAR HCT, AZOR, or TRIBENZOR, tell your doctor if you are pregnant or plan to become pregnant as soon as possible. Have not taken any other medicines to treat your high blood pressure beforeĬhildren that are less than 1 year of age must not receive BENICAR for high blood pressure.Are allergic to other sulfonamide type medicines.Are allergic to any component of this medicine.Have less urine than normal or if you cannot urinate.Take medicine that contains aliskiren and you have diabetes or kidney problemsĭo not take BENICAR HCT or TRIBENZOR if you:.Please see the WARNINGS AND PRECAUTIONS section of the Full Product Information about Fetal Toxicity.ĭo not take BENICAR, BENICAR HCT, AZOR, or TRIBENZOR if you: If you get pregnant while taking BENICAR, BENICAR HCT, AZOR, or TRIBENZOR, tell your doctor immediately.Talk with your doctor about other ways to lower your blood pressure if you become pregnant.BENICAR, BENICAR HCT, AZOR, and TRIBENZOR can cause harm or death to an unborn baby.WARNING: DO NOT TAKE BENICAR, BENICAR HCT, AZOR, OR TRIBENZOR DURING PREGNANCY ![]() Important Safety Information for BENICAR ®, BENICAR HCT ®, AZOR ®, and TRIBENZOR ® Along with lowering blood pressure, a complete treatment plan to lower the chance of a stroke or heart attack may include exercise, a diet low in sodium, stopping smoking, controlling cholesterol, treatment or prevention of blood clots, and controlling blood sugar.īENICAR, BENICAR HCT, AZOR, and TRIBENZOR may be used alone or with other medicines to treat high blood pressure.ĪZOR may be used as the first medicine to treat high blood pressure in people who are likely to need more than 1 blood pressure medicine to reach their blood pressure goals.ĪZOR is not for use as the first medicine to treat high blood pressure for people who are 75 years of age and older or have liver problems.īENICAR HCT and TRIBENZOR are not for use as the first medicine to treat high blood pressure. Patients may require more than one type of blood pressure lowering medication. The safety and effectiveness of BENICAR HCT, AZOR, and TRIBENZOR in pediatric patients have not been established. Medicines that lower blood pressure lower the chance of having a stroke or heart attack. BENICAR may be used in pediatric patients six years of age or older to lower high blood pressure. BENICAR, BENICAR HCT, AZOR, and TRIBENZOR are prescription medicines used to lower high blood pressure (hypertension) in adults. ![]() ![]()
![]() ![]() And I think 'Hey Bulldog' is very surreal. Paul McCartney recalled one of John Lennon's lesser-known, yet beloved tracks, “Hey Bulldog” - which was actually recorded on the fly during the video shoot for “Lady Madonna” in February 1968 and a highlight of the Yellow Submarine soundtrack: “One of the things that I like about John's songwriting style is it's quirkiness. They just took the music, we met with them, (and) they basically talked about basically what they're going to do.” George Harrison recalled how the Beatles were hardly the creative force behind the acclaimed Yellow Submarine film project: “Actually, the thing I liked most about the movie was we really didn't have to do anything to ( laughs) do it. And kids from all over the bloody world were shouting at me: ( Imitates a child): 'Why did you press the button?!'” Ringo Starr explained that upon the film's initial release in 1968, younger Beatles fans couldn't differentiate between the animated Ringo character and the flesh and bone drummer: “The thing with that film that still blows me away is that, like, the first year it was out, I had all these kids coming up to me saying, ( Imitates a child): 'Why did you press the button?!' ( Laughs) 'Cause, y'know I press that button and get shot out. The lyrics will appear on the bottom of the screen so the whole world can sing together as one during the coronavirus lockdown.” ![]() Rolling Stone reported that the full movie would air on the Beatles' official YouTube channel at 12 Noon ET on Saturday (April 25th) as a “one-time-only special event. But it still has an irresistible late ’60s spirit all of its own.Beatles fans young and old have the chance to enjoy the “Fab Four's” Yellow Submarine animated movie this weekend. In Beatles terms it feels like a ‘Sgt Pepper’ side project with a load of other off-cuts and outside influences merrily chucked into the pot. They’re voiced, a bit oddly, by actors and only appear briefly in a larking-about epilogue. It has flashes of winning silly humour (‘What day is it?’ ‘Sitar-day’), and who can resist the submarine turning into a cigarette lighter to the tune of the Hamlet cigar commercial? The Beatles themselves didn’t give a great deal to the film. But when already-existing songs like ‘Eleanor Rigby’, ‘Nowhere Man’, ‘All You Need Is Love’ and ‘Lucy In the Sky With Diamonds’ kick in, the whole thing soars and makes a strange sort of psychedelic sense. The fantastical story is happily all over the place, and the handful of songs written especially for the film aren’t especially memorable. Only The Beatles can help, and so an old sailor pitches up to Liverpool in a Yellow Submarine to collect them and take them on a mission to defeat the Meanies. Clearly influenced by Lewis Carroll’s Alice stories, ‘Yellow Submarine’ features a version of the band on the run through a series of hallucinogenic set-pieces involving bad folk called the Blue Meanies who are running riot in the seriously out-there Pepperland. ![]() ![]() But it’s weirder and scrappier than that, pitched somewhere dreamlike between childhood and adulthood. Now that the title track has become a nursery-school standard, you half expect this to be a kids’ cartoon. The Beatles put their name to no fewer than five films in their quick decade together, and while ‘Yellow Submarine’ isn’t the best of them (surely that’s ‘A Hard Day’s Night’?), it’s the only one to feature their ‘Sgt Pepper’ alter-egos in a trippy animated fantasy that feels like a Terry Gilliam-designed album cover come to life. ![]() ![]() ![]() The following Crystal Dynamics/Eidos Interactive Terms of Service (“Terms of Service”) explain the conditions that apply when you use our various games, software, products, services, websites, accounts, applications, online stores, features, content, and activities (the “Services,” and each a “Service”). See /DBCDisclosures for full promotional conditions.CRYSTAL DYNAMICS/EIDOS INTERACTIVE TERMS OF SERVICE Three-month special financing is available on select purchases (a minimum purchase may be required). 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By offering players vastly different ways to play, DEUS EX: HUMAN REVOLUTION challenges the foundation of gaming and provides an immersive experience where every choice has a lasting consequence.Coming in 2013 to the Nintendo Wii U, Xbox 360 and PS3 the Directors Cut features include visual improvements, overhauled boss fights, reinforced combat mechanics and much more making it the ultimate HUMAN REVOLUTION experience.įootnotes * Returns: The 30-day return period is calculated from invoice date. Adam Jensen, a man cybernetically augmented against his own choice, finds himself in the middle of a mysterious, global plot to which he holds the key. In DEUS EX: HUMAN REVOLUTION, the year is 2027 a time of great innovation in neuroprosthetics, but also a time of chaos, conspiracy, and social divide. Praised for its in-game art and cinema-quality storyline, DEUS EX: HUMAN REVOLUTION has garnered critical acclaim from the media and consumers alike since its original release in August 2011.
![]() Solar prominences photographed during the eclipse of May 28, 1900. They are a result of combustion of the hydrogen that envelopes the entire globe of the Sun. During this eclipse, the flames-called solar prominences-were proven to have their origin on the Sun, not the Moon. Early observers believed the flames were caused by “exhalations” or by volcanoes on the Moon. This eclipse is remarkable chiefly for the fact that it put an end to the mystery of the red flames seen around the dark disk of the Moon during totality. The Moon’s shadow came in from the Pacific Ocean near where Portland, Oregon, is now located, then moved northeastward across Washington Territory into Canada. Unfortunately, the maps of the area were so poor that he found himself just outside the path of totality-a misfortune for which he could hardly be blamed!Īccurate observations of solar eclipses in the 19th century were sparse until the solar eclipse of July 18, 1860. Professor Williams traveled to what is now Penobscot Bay in Maine, where the British naval officer in charge of the area allowed him to land long enough to make his observations. ![]() In 1780, Harvard College commissioned the Reverend Samuel Williams, Hollis Professor of Mathematics and Natural Philosophy, to observe the total solar eclipse predicted for October 27, 1780, although the Colonies were still at war with Great Britain. In, where it was total, I understand only the beginning was seen.” Jefferson went on to humbly request that Rittenhouse send him a more accurate timepiece-one designed to be “for astronomical purposes only.”ĭavid Rittenhouse. Thomas Jefferson, who was in Virginia at the time of the eclipse, wrote in a letter to Rittenhouse that “ were much disappointed in Virginia generally on the day of the great eclipse, which proved to be cloudy. There, it was observed by prominent astronomer David Rittenhouse, whose comments on the eclipse were published in one of the first volumes of the American Philosophical Society’s memoirs. The total solar eclipse of June 24, 1778, began in the middle of the Pacific Ocean and swept eastward, passing close to Philadelphia. In order to fully experience the eclipse, you will need to be within the path of totality.Advertisement Total Solar Eclipses through U.S. History The eclipse of 2024 will travel from the southwest to the northeast. The eclipse of 2017 traveled from the northwest to the southeast. In Nashville, 94.8% of the sun will be obscured during the eclipse if you travel to Memphis that number goes up to 98%. The path of totality will travel from Texas to Maine, unfortunately, Middle Tennessee is not within the path of totality this time around, however, we will see a Partial Solar Eclipse. ![]() ![]() The next total solar eclipse where the path intersects portions of the US will occur on April 8, 2024. If you missed the 2017 total eclipse, you’ll have another shot at seeing this amazing phenomena exactly five years from today! This is called “totality” and it’s something that many in Middle Tennessee got to experience on August 21, 2017. When this happens only a narrow path on the earth experiences the fully obscured sun for just a few minutes. A solar eclipse is a phenomenon that occurs when the moon passes between the Earth and the Sun.Ī total solar eclipse is when the moon lines up perfectly in a way that fully obscures the sun. ![]() ![]() ![]() I saw Common Core as very much a social justice issue.” “Oklahoma is notorious for its very low academic standards in mathematics, at least as far as mathematics teachers are concerned. “Wouldn’t it be great that students had the same standard wherever they moved, even if they left our state?” she asked. At a highly transient school like Taft, where she says 60 percent of the students who enroll in the fall have moved on and been replaced by others by the last day of school, Sparks saw the standards as a way to keep students on track even as they moved from school to school. Sparks says she was among the first teachers in Oklahoma to hear about Common Core, in 2009, before the draft standards were presented at the National Governors Association meetings the next year. Heather Sparks, an eighth-grade math teacher at Taft Junior High in Oklahoma City, helps students mold three-dimensional geometric solids. “They learned some things in the four years that we were working on the transition. “From the feedback I got, most teachers were disappointed by the state’s decision to overturn the Common Core,” Cobb said. Related: Opponents of Common Core open new fronts in battle against standards after a series of defeats “It happened in June, and when some teachers got back to work in August, there were several that hadn’t even followed the story,” said Rick Cobb, an assistant superintendent in Moore, a school district south of Oklahoma City. Oklahoma Teachers Trained for Three Years to Teach Common Coreĭespite the political turmoil, many classroom teachers in Oklahoma barely noticed the change at first. “The words ‘Common Core’ in Oklahoma are now so divisive that they have become a distraction,” she remarked. She signed it in June 2014, less than six months after her defense of the standards at the NGA meeting. Propelled by a national wave of local-control school politics and accusations that the Obama administration was guilty of “federal overreach” in education, HB 3399 sailed through the legislature and landed on Fallin’s desk. The goal is to ensure our children finish high school with better critical thinking skills and the tools they need to succeed in higher education or the workforce.”Ĭlassroom tools in David Woodside’s seventh-grade math classroom: pencil, scratch paper, clicker. Educators and school districts will still design lesson plans, choose appropriate textbooks and drive classroom learning. ![]() It is also not a federal curriculum in fact, it’s not a curriculum at all. “It is driven and implemented by those states that choose to participate. ![]() “Common Core is not a federal program,” she told her fellow governors. They learned some things in the four years that we were working on the transition. “From the feedback I got, most teachers were disappointed by the state’s decision to overturn the Common Core. She was chair of the bipartisan association at the time. 15, 2014 Fallin defended the standards in her State of the States Address at the National Governors Association in Washington. Mary Fallin, who took office in 2011, was an advocate of the new standards from the early days of her gubernatorial campaign. So why are kids spending weeks prepping anyway?Īs late as January 2014, it seemed certain that Oklahoma would start the coming school year under Common Core. Related: Common Core tests were supposed to be immune to test prep. Common Core may no longer be law in Oklahoma, but it has not disappeared from the classrooms. Yet more than half a year after the repeal, teachers like Sparks continue to use the standards. But in the summer of 2014, as Oklahoma school districts were to begin teaching the standards, the state legislature repealed Common Core, claiming that the federal government was using it to undermine local school control. Helping students discover mathematical relationships on their own is an idea that is central to Common Core, the educational standards adopted by more than 40 states, including Oklahoma. ![]() |